TTR and myocardial infarction: 25 CTs were found to be niche supporting cells that nurse cardiac stem cells and other cardiac cells in the myocardium and play an important role in regeneration following MI.26 Recently, we reported that the death of CTs is an important mechanism that contributes to the structural damage and poor healing and regeneration observed in MI.27, 28, 29 This evidence reveals that CTs provide a unique structural and functional microenvironment for maintaining the integrity of the myocardium and the regeneration of damaged myocardium.