HSF1 is a transcription factor of heat shock stress‐associated genes located in the cytoplasm as an inactive monomer and regulates the expression of heat shock protein genes after activation because of temperature stress.10, 11 Prior studies showed that HSF1 has a cardiac protective role as it prevents myocardial fibrosis and pathological cardiac hypertrophy during ischaemia injury and pressure overload.12, 13, 14 Recent studies suggest that activation of HSF1 may also stimulate the process of angiogenesis thereby reducing cardiac hypertrophy. Here, HSF1 is linked to cardiac hypertrophy.