HSF1 and cardiac hypertrophy: The outcome confirms one of our assumption that exercise training can improve the cardiac dysfunction associated with hypertrophy caused by pressure overload, which is in line with several previous studies.25, 26 Besides, in the Wild‐type mice, we found that the expressions of HSF1 and HSP70 were up‐regulated significantly both in the control group and pressure‐overload group after exercise training.