EGFR and hepatocellular carcinoma: Most recently, epidermal growth factor receptor has been discovered to play a critical role in mediating HBV‐NTCP internalization into hepatocytes.23 With the identification of the receptor, hepatoma cell lines that overexpress NTCP are susceptible to HBV infection.14, 24 As a bile salt transporter, NTCP is strongly expressed in parenchymal liver cells and is localized to the sinusoidal membrane.25 The expression NTCP in human non‐hepatic cells and hepatoma cells is lower than in human primary hepatocytes, which will limit HBV entry into these cells.