CD80 and familial pancreatic carcinoma: It was shown that downregulated miRNA‐212‐3p regulates the development of PCa through the secretion of inflammatory cytokines via the NF‐κB pathway.45 Another study showed that the regulatory effect of miR‐212‐3p in CD80 expression can be disrupted by the SNP rs1599795 in the 3′‐UTR of CD80, which may induce GC tumorigenesis.46 Ding et al47 suggested that IFN‐γ could be used as an immunological method to treat pancreatic cancer as it inhibits miR‐212‐3p expression and the subsequent upregulation of RFXAP and MHC class II.