In colorectal cancer cells, BCL-3 induces the post-translational stabilization of c-MYC (mediated by ERK1/2) increasing tumour xenograft size (49), while BCL-3 overexpression was shown to induce cell cycle progression, mediated by Cyclin D1 in hepatocellular carcinoma (43, 50), malignant melanoma (51) and breast cancer (52). Here, BCL3 is linked to hepatocellular carcinoma.