BCL3 and colorectal cancer: In colorectal cancer cells, BCL-3 induces the post-translational stabilization of c-MYC (mediated by ERK1/2) increasing tumour xenograft size (49), while BCL-3 overexpression was shown to induce cell cycle progression, mediated by Cyclin D1 in hepatocellular carcinoma (43, 50), malignant melanoma (51) and breast cancer (52).