Additional studies are necessary tobetter describe their roles in GBM biology and potential enrollment as biomarkers.In agreement, a study including 539 GBM cases identified and validated a geneexpression signature including 15 key DNA repair genes significantly correlated toprognosis, and five of them (CDK7, DDB2,RNH1, RFC2 and FAH) werehighly predictive of recurrence and disease-free survival (Kun et al., 2017). This evidence concerns the gene RNH1 and glioblastoma.