NEIL3 is a DNAglycosidase that participates of BER by removing oxidized bases, which can beinduced secondarily by IR, giving rise to apurinic/apyrimidinic sites that arerecognized and converted to single-strand breaks (SSB) by the endonuclease APEX2(Takao et al., 2009).These observations suggested a potential role for NEIL3 in themanagement of oxidative stress, supporting tumor progression. Here, NEIL3 is linked to neoplasm.