This article from Chen et al. [58], pointed out that extracted RNA of epithelial cell transforming sequence 2 oncogene (ECT2) from CTCs demonstrated a high potential to be a good diagnostic biomarker of CRC thanks to both interesting sensitivity and specificity, even in the cases were CEA concentrations accounted for less than 5 ng/mL (diagnostic threshold). The gene discussed is ECT2; the disease is colorectal carcinoma.