We found that the frequency of intratumoral FoxP3+ Tregs and A2aR+CD8+ T cells was tightly correlated with the TNM stage (P=0.025 and 0.003), lymph node metastasis (P=0.046 and 0.025), and distant metastasis (P=0.015 and 0.020). This evidence concerns the gene ADORA2A and metastatic malignant neoplasm in the lymph nodes.