It has been reported that miR-27b is down-regulated in in vitro cultured adipocytes and adipose tissue in obesity-related models and that miR-27b impairs adipocyte differentiation in 3T3-L1 cells and human adipose-derived mesenchymal stem cells via its associations with PPARγ and C/EBPα [24–27]. Here, PPARG is linked to obesity due to melanocortin 4 receptor deficiency.