For instance, the overexpression of TRIB2 may accelerate the acute myeloid leukemia (AML) through activating C/EBPα pathway [22]; in liver cancer, TRIB2 promoted cell proliferation and transformation via improving the stabilization of YAP through the E3 ubiquitin ligase βTrCP [23]. Here, TRIB2 is linked to acute myeloid leukemia.