POMC and adrenocortical insufficiency: Adrenocortical insufficiency as an irAE also could not be denied (eosinophil 31.0%, Na 131 mmol/L, ACTH 14.0 pg/mL, and cortisol 6.2 μg/dL), so hydrocortisone 15 mg/day was started before levothyroxine administration.