Published findings support that the canonical dauer regulatory signaling pathways in C. elegans, G protein-coupled sensory signaling, insulin-like signaling and steroid-nuclear receptor (NR) signaling involving homologs of the DAF-12 NR, and its dafachronic acid ligands are conserved in several soil-transmitted parasitic nematode species, including Strongyloides spp., and operate in sequence to regulate developmental arrest of iL3 in the environment and their reactivation following host infection [76]. The gene discussed is IL3; the disease is infection.