The treatment with immunosuppressive agents (azathioprine, cyclosporine, cyclophosphamide, and methotrexate) [36, 37], IVIG, anakinra [38] (IL-1 receptor antagonist), and canakinumab [39] (IL-1β blocking monoclonal antibody), may be considered only in cases of recurrent pericarditis which is refractory or intolerant to conventional treatments, but data for their use are limited, and should be tailored to the specific individual patients. This evidence concerns the gene IL1B and pericarditis.