Although the sequence conservation of threonine at position 240 is lower than that of leucine at position 272 (Figures 1(d) and 1(e)), there have been at least 16 reported PD patients with PRKN p.T240M, p.T240R, or p.T240A variants in homozygous or compound heterozygous states (Table 1) [6, 14–21]. This evidence concerns the gene PRKN and Parkinson disease.