Other findings have showed that vascular endothelial growth factor-induced angiogenesis is inhibited by Sema3A in the breast cancer cell line and that Sema3A modulates phosphorylation of PTEN and FOXO3a and expression of MelCAM, leading to suppression of tumor growth and angiogenesis using an in vivo breast cancer mouse model [39]. This evidence concerns the gene MCAM and breast carcinoma.