ADRB3 and fatty liver disease: In adult mice with the adipocyte-specific deletion of Berardinelli-Seip congenital lipodystrophy type 2 (i.e., Bscl2), the expression of ADRB3 protein was downregulated in mature adipose tissue, which increased the development of high-fat diet-induced hepatic steatosis despite reducing adrenergic-stimulated lipolysis [15].