The pathogenicity of survivin expression has three main aspects: (a) it inhibits and disorders apoptosis and stimulates cell proliferation; (b) it stimulates angiogenesis factors and leads to excessive proliferation of vascular endothelial cells, while promoting local ischemia that further activates angiogenesis, thus forming a vicious circle; and (c) its specific binding reaction with spindle microtubules in the premitotic phase causes tumor cells to escape monitoring at the G2/M phase of the cell cycle. This evidence concerns the gene BIRC5 and neoplasm.