In particular, molecular modeling/docking studies on liquiritigenin have shown that it can form stable complexes with aromatase, and the selective estrogen receptor modulator (SERM) effect and relevance of the estrogen receptor (ER) modulating elements CECR6, NKG2E, and NKD in MCF-7 human breast cancer cells have been reported [52]. This evidence concerns the gene TMEM121B and breast cancer.