Also our patients with high gal.3 were associated with significantly lower CR rate compared to low Gal.3 level, which was explained by Hu et al. [37], that high gal-3 level resulting in chemotherapy resistance in acute leukemia in vitro cell lines and vivo studies via activating target genes, cyclin D1, c-Myc and surviving. Here, CCND1 is linked to acute leukemia.