ADIPOR1 and hepatocellular carcinoma: Epithelial-mesenchymal transition (EMT) increases the migratory capacity of epithelial cells and plays a key role in the metastasis of cancer cells [105]; some reports show that the miR-221 promotes EMT in HCC cell lines by targeting on adiponectin receptor 1 (AdipoR1) and cytokine signaling 3 (SOCS3), which implies that the JAK/STAT3 signaling pathway may be involved [44, 45].