Scientists investigated the role of ADAM-17 (a disintegrin and metalloprotease 17) as a novel multidrug resistance (MDR) mechanism in multidrug-resistant CRC and found that miR-222 was directly targeting on ADAM-17, which was downregulated in multidrug-resistant CRC cells and increased cancer cells' apoptosis. Here, ADAM17 is linked to colorectal carcinoma.