The upregulation of miR-222 was correlated with the deterioration of cervical cancer, and the analysis showed that p27/Kip1 and PTEN were negatively correlated with miR-222, which affected the proliferation and migration of Hela cells and SiHa cells, suggesting that miR-222 might be a new target for cervical cancer therapy. This evidence concerns the gene PTEN and cervical cancer.