INS and type 2 diabetes mellitus: In a multicenter cross-sectional GENFIEV (GENetics, PHYsiopathology, and EVolution of Type 2 diabetes) study, 1 hPG >155 mg/dl showed lower insulin sensitivity, impaired β-cell function, and worse cardiovascular risk profile (glycosylated hemoglobin, blood pressure, low-density lipoprotein cholesterol, and triglyceride) [56].