This has formed a basis of many studies in 1990s like Diabetes Interventional Study, Kumamoto study, DIGAMI (Diabetes and Insulin-Glucose infusion in Acute Myocardial Infarction) study, and STOP-NIDDM (Study TO Prevent NIDDM) trial to control the postprandial hyperglycemia in order to prevent CVD [45]. This evidence concerns the gene INS and type 2 diabetes mellitus.