F2 and psoriasis: The top 13 canonical pathways induced by the altered proteins include LXR/RXR activation, fatty acid β-oxidation I, valine degradation I, TCA cycle II (eukaryotic), creatine-phosphate biosynthesis, mitochondrial dysfunction, intrinsic prothrombin activation pathway, acetyl-CoA biosynthesis I (pyruvate dehydrogenase complex), atherosclerosis signaling, ethanol degradation II, stearate biosynthesis I (animals), role of IL-17A in psoriasis, and acute-phase response signaling (Figure 4).