To determine the putative fluctuations in Wnt signaling during the progression of SJS/TEN, expression levels of genes related to Wnt signaling in T cell function, including LEF1, TCF1, LRP5, and LRP6, were assessed in blister cells from SJS/TEN patients and compared with that in PBMCs from SJS/TEN patients and from normal subjects. The gene discussed is LRP5; the disease is toxic epidermal necrolysis.