ANGPT2 and rheumatoid arthritis: In another investigation, two SNPs in Angpt2 (rs1868554 and rs2442598) were significantly associated with acute lung injury in clinical stage II 13, while another study reported an association between five Angpt2 variants (s2442598, rs734701, rs1823375, rs11137037 and rs1267482) and associated with the risk of developing rheumatoid arthritis 17.