VEGFA and gastric ulcer: Hiruma-Lima and coworkers, identified in C. americana bark extract monomeric and polimeric catechins beyond of mixture of procyanidins, that could explain the excellent healing activity on gastric ulcers in addition to gastroprotective effect by increasing the production of prostaglandin E2 (PGE2) in the mucosa [20] and consequent induction of significant increase in vascular endothelial growth factor (VEGF) expression leading to angiogenesis [48,49].