Using unique up-regulated genes after differentiation to each of the major T helper subsets [64], our data showed that Yap-cKO CD4+ TILs are more skewed towards a Th2 and Treg phenotype compared to WT CD4+ TILs (S4A–S4D Fig), consistent with prior studies showing that the B16F10 tumor microenvironment enhances these fates [65–67]. The gene discussed is CD4; the disease is neoplasm.