As for FGFR, accumulating evidence supports FGFRs as a new therapeutic target for breast cancers, especially for high-level FGFR1- and FGFR2-amplified cancers.29,30 However, in this study, two patients revealed high-level FGFR amplification in the smaller lesion. This evidence concerns the gene FGFR2 and breast carcinoma.