Upon copy number analysis in eight patients, inter-lesional differences in PTEN loss and MYC amplification were observed.14 They also investigated whether inter-lesional heterogeneity was associated with clinicopathologic factors and found that the only association that existed was with inter-lesion distance.14 The distance between the tumours ranged from 0.3 to 7.0 cm (mean 2.4, median 1.9) in their study.14 In our study, the distance between tumours was not drastically different, ranging from 0.5 to 4.5 cm (mean 1.7, median 1.0). This evidence concerns the gene PTEN and neoplasm.