ADGRL3 and attention deficit-hyperactivity disorder: Latrophilins (Lphn1–Lphn3 in mammals) are adhesion G-protein-coupled receptors (GPCRs) that have received attention because of their role as a calcium-independent receptor of latrotoxin (Davletov et al., 1996, Krasnoperov et al., 1996, Lelianova et al., 1997), their recently reported functions as mechanosensitive receptors (Liebscher and Schöneberg, 2016, Scholz et al., 2015, Scholz et al., 2017, Stoveken et al., 2015), and their roles in neurodevelopment disorders such as attention deficit hyperactivity disorder (ADHD) (Domené et al., 2011, Lange et al., 2012, van der Voet et al., 2016).