EGFR and neoplasm: The EGFR tyrosine kinase inhibitor dacomitinib (9), which has been primarily used against non-small-cell lung carcinoma, significantly inhibited intracranial tumor growth by using mice xenografted with GBM cells, which was evidenced by a reduction of tumor cells proliferation and an induction of apoptosis of tumor cells (Zahonero et al., 2015).