Unexpectedly, we also found that certain rhythm genes such as SERPINE1, TIMELESS, NFIL3, and ARNTL2, which are positively correlated with the infiltration of all immune cells, are risk factors for cancer prognosis in pan‐cancer, suggesting that it is necessary to consider the comprehensive effects of cancer progression and cancer immunity caused by genome instability when evaluating the roles of certain rhythm genes in the prognosis of cancer. The gene discussed is SERPINE1; the disease is cancer.