As expected, certain rhythm genes such as DBP that positively correlated with the infiltration of T lymphocytes also predict benefit prognosis, whereas certain rhythm genes such as SERPINE1, NPAS2, NFIL3, and CSNK1D that negatively correlated with the infiltration of T lymphocytes predicts poor prognosis of cancer patients. The gene discussed is NFIL3; the disease is cancer.