BRCA1 and Gardner syndrome: The relative risk of radiation doses above 44 Gy is 30.6 compared to doses below 15 Gy [16].The incidence of radiosarcoma is also affected by a variety of other factors, such as BRCA1 gene mutations [17, 18], hereditary diseases (such as Gardner syndrome and Li–Fraumeni syndrome), chemotherapy with alkylating agents [19].