Mice with CLP-induced ALI exhibited decreased Bcl-2 protein expression and increased Bax, Bax/Bcl-2, cleaved caspase 3 and cleaved caspase 9 protein expression in lung tissue samples compared to that in the sham group, whereas the expression changes in the proteins were reversed by AAV-TIPE2 and DEX treatment. The gene discussed is TIPE2; the disease is acute respiratory distress syndrome.