Some examples are the DUX4 gene involved in FSHD,6 the nuclear factor κB (NF-κB) gene in the mdx mouse model of Duchenne muscular dystrophy,7 the RNA polymerase of the coxsackievirus B3 to prevent CoxB3-mediated cardiomyopathy,8 the NADPH oxidase gene to prevent cold-induced hypertension in rats,9 and the phospholamban (PLB) gene for improved calcium cycling to prevent heart failure.10 Here, PLN is linked to cardiomyopathy.