Cyclophilin A (CypA), which is encoded by the peptidylprolyl isomerase A gene, is a small molecule protein located in the cytoplasm and the extracellular space, and it has been widely used as a target of immunosuppressant after organ transplantation for anti-rejection purposes as well as in the treatment of autoimmune diseases [10]. Here, PPIA is linked to autoimmune disease.