To check whether YAP inhibition could suppress therapy resistance mediated by MYPT1 downregulation in vivo, we generated xenografts with SKOV3 ovarian cancer cells expressing EV or shMYPT1 and cohorts of 5 mice each were treated with cisplatin, verteporfin or both drugs (Fig. 5d). The gene discussed is PPP1R12A; the disease is ovarian carcinoma.