C1orf54 and systemic lupus erythematosus: The most frequent alterations were Acidic Nuclear Phosphoprotein 32 Family Member E (ANP32E) (34.78%), Aph-1 Homolog A (APH1A) (34.78%), and Chromosome 1 Open Reading Frame 54 (C1orf54) (34.78%), etc. KEGG pathway analysis of co-occurrence genes showed enrichment in complement and coagulation cascades and systemic lupus erythematosus (Figure 6B).