CHEK1 and hepatocellular carcinoma: For mining regulators potentially responsible for PRPF3 dysregulation, we found that PRPF3 in HCC is associated with a network of kinases including CDK1, PLK1, AURKB, CHEK1, and CDK2. These kinases regulate genomic stability, mitosis, and the cell cycle, and showed differential expression and survival prognosis in LIHC.