PRPF3 expression showed a strong positive association with expression of SETDB1 (positive rank #1, r = 0.672, p = 5.06E-50), VPS72 (r = 0.658, p = 2.19E-47), and VPS45 (r = 0.647, p = 1.95E-45), etc. Notably, the top 50 significantly positive genes showed the high likelihood of being high-risk genes in HCC, in which 34/50 genes were with high hazard ratio (HR) (p < 0.05). Here, VPS72 is linked to hepatocellular carcinoma.