Finally, to broaden the understanding of PRPF3 crosstalk with immune genes, we analyzed the correlations between PRPF3 expression and various immune signatures, which included immune marker genes of 28 tumor-infiltrating lymphocytes (TILs), immune inhibitory or stimulatory genes (including immune checkpoint gene sets), cytokine-related genes, cancer-testis antigen genes, and major histocompatibility complex (MHC) genes (Table 2 and Supplementary Table 9). This evidence concerns the gene HLA-C and neoplasm.