For mining regulators potentially responsible for PRPF3 dysregulation, we found that PRPF3 in HCC is associated with a network of kinases including CDK1, PLK1, AURKB, CHEK1, and CDK2. These kinases regulate genomic stability, mitosis, and the cell cycle, and showed differential expression and survival prognosis in LIHC. The gene discussed is PRPF3; the disease is hepatocellular carcinoma.