While we found that MIR100HG was equally distributed in cytoplasm and nucleus in normal lung fibroblasts, MIR100HG is predominantly located in the nucleus of human megakaryotic leukemia cells (CMK) (Emmrich et al., 2014) and osteosarcoma (U2OS) cells (Sun et al., 2018). Here, MIR100HG is linked to osteosarcoma.