In summary, this study, for the first time, uncovers the probone metastatic function of PCAT7, which forms a positive feedback loop with TGF‐β signaling in PCa, indicating PCAT7 may serve as a promising therapeutic target in PCa via disrupting the PCAT7‐miR‐324‐5p‐TGF‐β loop. Here, TGFB1 is linked to posterior cortical atrophy.