Tumor microenvironment (TME) reprograms TAN to promote the secretion of protumorigenic factors including reactive oxygen species, arginase‐1, IL‐8, VEGF, and MMP‐9 (Clappaert et al., 2018; Fridlender et al., 2009; Mollinedo, 2019; Powell and Huttenlocher, 2016; Whyte et al., 2018). Here, CXCL8 is linked to neoplasm.