SQSTM1 and diabetic kidney disease: Bone morphogenetic protein (BMP) and activin receptor membrane binding inhibitor (BAMBI), a competitive receptor antagonist of the gfb receptor family, are expressed in GECs and regulated by autophagy in TECs.42 High glucose inhibits autophagy and results in p62/SQSTM1 protein accumulation in the TECs of DKD patients, while p62/SQSTMl is mainly degraded by autophagic lysosomes, suggesting that the autophagy pathway is inhibited in renal tissue.