eNOS deficiency caused by GEC damage, combined with the effect of hyperglycaemia, leads to TEC damage, and damaged TECs cannot produce enough VEGF‐A, leading to a vicious cycle.28 Expression of VEGF is decreased in renal biopsy tissues of diabetic patients, and expression of VEGF is negatively correlated with proteinuria, while patients with VEGF antibodies were at risk of GEC injury. Here, VEGFA is linked to Hyperglycemia.