SGLT2 expressed by proximal TECs determines the reabsorption of renal blood glucose.31 In DKD patients, more glucose molecules enter the renal tubules, which results in increased SGLT2 expression, a large number of Na+ and glucose molecules transporting back to the blood through SGLT2, and decreased Na+ flowing through the MD. The gene discussed is SLC5A2; the disease is diabetic kidney disease.