This category also includes many known biomarkers for cancer diagnosis or targeted treatment, such as APC Q1291* (for COAD), EGFR L858R (for LUAD), BRAF V600E (for THCA and SKCM), DNMT3A R882H and NPM1 W288Cfs*12 (for LAML). Here, DNMT3A is linked to cancer.