KMT2D and cancer: Among significant correlations, cancer diversity of mutations negatively correlates with VAFs in BRAF, KIT, PREX2, NRAS, and SF3B1 but positively correlates with VAFs in FBXW7, KMT2D, NF1, and SPOP. After examining the mode of action of these driver genes, we found that OGs involved more negative correlation relationships, and TSGs included more positive correlation relationships (Fig. 4b).