RCC risk has been found to be associated with interactions between alcohol consumption and ADH726; sodium and hypertension and AGTR, AGT and ACE31; calcium and vitamin D intake and RXRA28; tobacco smoking and NAT2, CYP1A1 and GSTM125; and meat-cooking mutagens and ITPR2 and EPAS127. The gene discussed is AGT; the disease is hypertensive disorder.