In multivariable-adjusted analyses a non-significant inverse association was observed between both VHL_rs1642739 (HR 0.45, 95%CI 0.12–1.69) and VHL_rs265318 (HR 0.38, 95%CI 0.07–2.00) and VHL promoter methylation in ccRCC cases. This evidence concerns the gene VHL and nonpapillary renal cell carcinoma.