Overexpressing the MYC proto-oncogene in adult mouse liver cells with the Tet system (Tet-o-MYC/LAP-tTA) by discontinuing doxycycline treatment reproducibly turns on MYC (MYC-ON) and induces a liver cancer that resembles hepatocellular carcinomas and/or hepatoblastomas25. Here, CEBPB is linked to hepatocellular carcinoma.