As expected, the antibody-mediated depletion of either CD4+ or CD8+ T cells impaired the Arf1-ablation-induced tumor suppression in both Lgr5/Apc and MYC-ON mice; the depletion of CD8+ T cells had a stronger effect than the depletion of CD4+ T cells, and the depletion of both CD8+ and CD4+ T cells had an additive effect. The gene discussed is LGR5; the disease is neoplasm.