We found that the tumors in sh-Scram-B16 mice metastasized to lung (Supplementary Fig. 10e, f), kidney (Supplementary Fig. 10g), and testis (Supplementary Fig. 10h) after 15 days of injection, while the tumors in sh-Arf1-B16 mice had negligible tumor metastasis. The gene discussed is ARF1; the disease is neoplasm.