MAVS and neoplasm: Interestingly, it was recently reported that low-dose DNA-demethylating agent (5-AZA-CdR) treatment40 or histone demethylase LSD1 ablation41 can induce the formation of dsRNA that “tricks” cancer cells into behaving like virus-infected cells, which promotes an MDA5/MAVS-dependent state of “viral mimicry” and stimulates anti-tumor immune responses.