We further tested these inhibitors in MYC-ON mice, and similarly found that that ARL had no effect on the Arf1 inhibitor GCA-treated mice, while oxATP, suramin, and the TLR4 inhibitor dramatically blocked the anti-tumor effect of GCA (Fig. 6d–f, and Supplementary Fig. 9b–d). Here, TLR4 is linked to neoplasm.