ARF1 and neoplasm: Our real-time PCR also revealed that the PD-L1 expression was significantly decreased in Lgr5/Arf1/Apc mice (Supplementary Fig. 4w), in the liver of MYO-ON mice treated with GCA compared with DMSO (Supplementary Fig. 4x), and in the tumor of BALB/c mice injected with murine colon carcinoma CT26 cells treated with GCA (Supplementary Fig. 4y) or with murine breast carcinoma 4T1 cells treated with GCA (Supplementary Fig. 4z).