In line with our finding that Arf1 inhibition increased the T-cell infiltration and activation in mouse models, the Arf1 expression level was found to be inversely correlated with IL-1β expression (Supplementary Fig. 16d), T-cell infiltration (Supplementary Fig. 16e), and INFγ expression (Fig. 7l) in a variety of cancer types in the The Cancer Genome Atlas (TCGA) cancer patient dataset. This evidence concerns the gene IL1B and cancer.