Tunicamycin can induce the ER stress, we also treated the MYC-ON mice with Tunicamycin plus BFA and found that co-treatment with the two inhibitors can further reduce the tumor number (MYC-ON/DMSO: 63.0 ± 18.0; MYC-ON/BFA: 16.8 ± 7.5; MYC-ON/Tuni: 47.3 ± 19.8; MYC-ON/BFA+Tuni: 5.8 ± 5.0) (Supplementary Fig. 11m, n). The gene discussed is MYC; the disease is neoplasm.