The growing evidence suggests that signal transducer and activator of transcription 3 (STAT3) and p65, a subunit of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB p65), have a pivotal role in mediating the positive feedback loop in psoriasis by translocating to the nucleus and stimulate transcription of proliferation and inflammation-regulated genes expression. This evidence concerns the gene NFKB1 and psoriasis.