A significant decrease in tumor control was observed in Ifngr1−/− mice treated with Prdm1−/−Trp1 cells (Figures 7J and S6H), which is consistent with the data in Figure 1F and the idea that both helper and cytotoxic activities contribute to the potent anti-tumor activity of Trp1 cells in the context of ACTs. The gene discussed is IFNGR1; the disease is neoplasm.