Increased expression of genes associated with Cγ chain cytokine signaling and the response to IL-2 in Trp1 Th-ctx is consistent with the cytokine milieu induced by lymphodepletion (Williams et al., 2007) and could offer mechanistic insights into the acquisition of cytotoxic activity by tumor-reactive CD4+ T cells in vivo. This evidence concerns the gene CD4 and neoplasm.