GZMB and neoplasm: The transcriptome of activated CD4+ TILs from αCTLA-4-treated sarcoma showed a similar pattern of expression, marked by a decrease in the Tfh-cell-associated genes Tcf7 and Bcl6. This transcriptional program of tumor-infiltrating CD4+ Th-ctx cells was similar to that shown in viral-reactive CD4+GzmB+ T cells (Donnarumma et al., 2016) but contrasts with prior studies showing T-bet-dependent differentiation of CD4+GzmB+ in a viral model (Hua et al., 2013).