We used the tg37+/− mouse model of prion disease, which has been extensively characterized with respect to PERK-eIF2α signaling and its modulation, particularly in neurons (Halliday et al., 2015, Halliday et al., 2017, Moreno et al., 2012, Moreno et al., 2013). The gene discussed is EIF2A; the disease is prion disease.