We used the tg37+/− mouse model of prion disease, which has been extensively characterized with respect to PERK-eIF2α signaling and its modulation, particularly in neurons (Halliday et al., 2015, Halliday et al., 2017, Moreno et al., 2012, Moreno et al., 2013). This evidence concerns the gene EIF2AK3 and prion disease.