HK2 and lung cancer: The study by Ma Y also revealed that the echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK) was coupled to overexpression of hexokinase II (HK2), one of the rate-limiting enzymes of the glycolytic pathway, which induced hyperactive glycolysis in EML4-ALK-positive lung cancer [32].