Regarding lesion distribution, ALK-positive ALCL was found to be more likely to involve the lymph nodes than ALK-negative ALCL; 84.3% (27/32) of ALK-positive ALCLs were observed to have positive lymph nodes compared to 55.5% (10/18) of ALK-negative ALCLs (χ2 = 4.973, P = 0.043). This evidence concerns the gene ALK and anaplastic large cell lymphoma.