In comparing patients with mutations in CBP (n = 308) and EP300 (n = 52), there is no significant difference in observed rates of postnatal growth retardation, overall rate of intellectual disability, nor several of the anatomical abnormalities (e.g., cardiovascular anomalies, urinary tract anomalies, scoliosis, obesity and presence of keloids). The gene discussed is CREBBP; the disease is Intellectual disability.