An increasing number of studies on the outcomes and prediction of disease relapse in IgG4-RD showed that high baseline serum IgG4, IgE, and eosinophilia could predict IgG4-RD relapse independently [15]; eosinophilia, higher baseline RI, having five or more organs involved, and dacryoadenitis were risk factors for remission induction failure with GC monotherapy [16]; and hypocomplementemia was more frequent in IgG4-related kidney disease (IgG4-RKD), which may participate in the disease development [17, 18]. This evidence concerns the gene IGHE and Increased total eosinophil count.