In contrast, the most relevant upregulated genes in ASD were those coding for constituents of the muscle contractile apparatus such as ACTA1, MYOT, MYL3, MUSTN1, MYH11, NEB, MURC, and ENO3 (Table 1), whose functional interactions were predicted by network analysis (Fig. 2b). The gene discussed is ENO3; the disease is atrial septal defect.