GADD45B and cardiac hypertrophy: Among them, those coding for DUSP family members, CDKN1A, BTG2, GADD45B,34, and MCL-1 have been previously shown to be upregulated in human myocardial tissues in response to stress and/or DNA damage and to play a role in the regulation of cardiac hypertrophy and remodeling in animal models [74–78].