In contrast, the most relevant upregulated genes in ASD were those coding for constituents of the muscle contractile apparatus such as ACTA1, MYOT, MYL3, MUSTN1, MYH11, NEB, MURC, and ENO3 (Table 1), whose functional interactions were predicted by network analysis (Fig. 2b). This evidence concerns the gene MYH11 and atrial septal defect.